In sharp contrast, exposure to IL-15 and IL-21 induced a highly significant release of IFN-γ in 4-week old cultures, corresponding to a mean of 1210 ± 245 pg/ml in 10 independent experiments.
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Interleukin-21 induces the differentiation of human umbilical cord blood CD34-lineage- cells into pseudomature lytic NK cells.
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