Streptococcus pneumoniae nasopharyngeal colonization induces type I interferons and interferon-induced gene expression.

Messages encoding immunoglobulin heavy chain subunits (Igh-1a and Igh-VJ558) were also more abundant at this time point and there was a highly significant overlap with a set of transcripts that were abundant in germinal center B cells following antigen-specific activation within the lymphoid tissue ( p ≤ 4E-6) [ 71 ].

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