Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis.

The data showed a slight trend - which was not statistically significant - toward Gpc1 -/- embryos being delayed by about 1 somite (at E8.5, wild type = 11.5 ± 2.8 and mutant = 10.3 ± 3.2; at E9.5, wild type = 22.0 ± 2.4 and mutant = 21.2 ± 2.4).

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The major phenotype associated with Gpc1 loss is a highly significant reduction in brain size, with only subtle effects on brain patterning (confined to the anterior cerebellum).

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