The synthetic Plasmodium falciparum circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial.

PLoS One · 2009 · PMC2749339 · PMID 19798415

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a slight trendno p-value reported

There was a slight trend towards an increase in the frequency of systemic AE with increasing peptide dose but this was statistically significant only for arthralgia ( p = 0.0455).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.