Viral load levels measured at set-point have risen over the last decade of the HIV epidemic in the Netherlands.

PLoS One · 2009 · PMC2753776 · PMID 19809510

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an increasing trendno p-value reported

Evidence of an increasing trend [18] or a stable level [7] , [19] in CD4 cell count might reflect a shorter study period.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.