Mutations in the DNA-binding domain of NR2E3 affect in vivo dimerization and interaction with CRX.

First, the adRP-linked p.G56R mutant showed a highly significant decrease in NR2E3 WT -mediated rhodopsin transactivation by 50% already at a NR2E3 WT /NR2E3 G56R ratio of 2∶1 (p<0.01 by ANOVA test for p.G56R vs all other mutants).

also in 132,142 other papers