Mouse HORMAD1 and HORMAD2, two conserved meiotic chromosomal proteins, are depleted from synapsed chromosome axes with the help of TRIP13 AAA-ATPase.

PLoS Genet · 2009 · PMC2758600 · PMID 19851446

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0.0096

closest p · 0.2× alpha

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marginally significantp<0.0096actually significant

Localization of HORMADs in pachytene spermatocytes Median HORMAD1/2 signal intensities on synapsed axes decrease slightly as cells progress from zygotene to pachytene ( Figures 5A, 5B ; Mann-Whitney U test, p = 0.08 (marginally significant) for HORMAD1 and p<0.0096 for HORMAD2), while the intensity of SYCP1 signal increases during this time ( Figures 5A, 5B ; p<0.0001).

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