This reduction effect of the 259/259 genotype did not show, however, a trend towards significance which might be explained by the small size of the group and the large variability in SNCA -mRNA levels within each genotype group (resulting from the neuronal cell heterogeneity of the mid brain/substantia nigra tissue) [12] .
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Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues.
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