Study of human RIG-I polymorphisms identifies two variants with an opposite impact on the antiviral immune response.

2C shows a moderate but highly significant constitutive IFN-β expression and IRF-3 activity -but no NF-κB activity (not shown)- in WT RIG-I-transfected cells (n = 3, p <0.001 when compared to control vector-expressing cells), in agreement with the fact that RIG-I is especially prominent in signaling pathways leading to type I IFNs [2] , [3] , [4] , [15] .

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