Concordant regulation of translation and mRNA abundance for hundreds of targets of a human microRNA.

The overall effects on translation, while highly significant, were very modest; on average, the estimated translation rates of miR-124 Ago IP targets decreased by 12% relative to nontargets (15% for miR-124 IP targets with a 7mer 3′-UTR seed match and 5% for miR-124 IP targets without a 7mer 3′-UTR seed match) ( Figure 4C , right).

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