Intrinsic structural disorder confers cellular viability on oncogenic fusion proteins.

PLoS Comput Biol · 2009 · PMC2768585 · PMID 19888473

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highly significantno p-value reported

We found that while the actual number of truncated domains in the 255 translocation partner proteins with an established breakpoint was 48, the random breakpoints (repeating the random selection process 200 times) resulted in 76.2 domain truncations on average with a standard deviation of 5.6, that is, the difference is highly significant, with a Z-value of 4.87.

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