Efficacy dilution in randomized placebo-controlled vaginal microbicide trials.

Emerg Themes Epidemiol · 2009 · PMC2768687 · PMID 19818138

Europe PMC DOI

hedged sentence

0.1000

closest p · 2.0× alpha

0.1000

boldest claim

The sentences

of borderline significancep = 0.10so close (0.05 < p ≤ 0.1)

More recently the HPTN-035 trial of 0.5% PRO2000 gel (Endo Pharmaceuticals, Chadds Ford, PA, USA), a viral entry inhibitor, reported an estimated effectiveness of 30% (95% CI [-8%; 54%]) which, although of borderline significance (p = 0.10), was welcomed with optimism [ 3 ].

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