Recently, Ke Q et al [ 21 ] found that none of four potentially functional SNPs (-2578C>A, -1498T>C, -634G>C, and +936C>T) of the VEGF gene or their haplotypes achieved a significant difference in their distributions between gastric cancer cases and controls in a Chinese population, whereas in a Greek study of the association between these four potentially functional SNPs in VEGF and gastric cancer risk in 100 cases and 100 controls [ 38 ], it was found that the -634CC variant genotype was associated with an increased the risk of gastric cancer with a marginal significance.
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The VEGF -634G>C promoter polymorphism is associated with risk of gastric cancer.
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