Murine pancreatic beta TC3 cells show greater 2', 5'-oligoadenylate synthetase (2'5'AS) antiviral enzyme activity and apoptosis following IFN-alpha or poly(I:C) treatment than pancreatic alpha TC3 cells.

Exp Diabetes Res · 2009 · PMC2771153 · PMID 19888425

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highly significantno p-value reported

More recently, we found a highly significant association between basal 2′5′AS activity and an A/G splice acceptor site single nucleotide polymorphism (SNP) in the OAS1 gene, indicating that basal activity of this enzyme is strongly genetically controlled [ 11 ].

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