Long-term therapy in COPD: any evidence of adverse effect on bone?

90 , 91 An increased risk for fractures has been shown for doses above 5 mg/day within 3 to 6 months after initiation of OCS therapy, 78 , 89 and for doses of ≥10 mg prednisolone for less than 60 days with an increasing trend by time. 83 Vestergaard and coworkers also found an effect of lower doses within 60 days, but this effect did not last beyond 2 months, and was probably an effect of confounding by indication.

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