highly significantp < 0.005
ANOVA for repeated measures for delta DHEA concentration showed no effect of subject group ( F 1,48 = 0.004, p = 0.95) on delta DHEA, although there were highly significant dose ( F 2,48 = 6.2, p < 0.005), time and time–dose interaction effects (both p < 0.001) (Figure 3 ).