iTRAQ-based proteomics profiling reveals increased metabolic activity and cellular cross-talk in angiogenic compared with invasive glioblastoma phenotype.

Quantification of the staining intensity demonstrated a highly significant ( p < 0.001, Wilcoxon rank test) increase in protein expression for Calnexin (1.6-fold) and AnxA2 (1.5-fold) and a 1.3-fold increase of AnxA5 (at the border of significance, p = 0.05) ( Fig. 6 ).

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