A combinatory approach for selecting prognostic genes in microarray studies of tumour survivals.

Using exactly the same assignment of training (59 samples) and testing (57 samples) sets, we applied the above described procedure to the training set and selected a 23-gene expression signature for predicting the testing set (gene filtering with P < .005 leaving 70 highly significant genes for ranking and optimization; mean survival 384 days in the training set and 544 days in the testing set) with SERR ̄ ( 23 ) = 0.82 .

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