highly significantP < 0.05
Statistical differences were declared as significant and highly significant at P < 0.05 and P < 0.01.
Statistical differences were declared as significant and highly significant at P < 0.05 and P < 0.01.
There were few significant metabolic pathways within the 2,102 DEG which we considered marginally significant (FDR ≤ 0.06; Table 3 and Additional File 6 ).