Barely Significant
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Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells.

PLoS One · 2009 · PMC2785884 · PMID 20011585

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highly significantno p-value reported
When the IPA software was used to analyze the probe sets there were 26 significant regulatory networks (score>2), of which 5 were highly significant (score>20).

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.