Meta-analysis of inter-species liver co-expression networks elucidates traits associated with common human diseases.

Of the 22 genes in the immediate neighborhood of ApoE , including ApoE itself, 4 (18.2%) were inferred as differentially connected between the wild type and ApoE −/− crosses, and this proportion was highly significant (∼8.1 fold enrichment, FET p -value<1.1×10 −4 , permutation adjusted p -value<0.001) ( Figure 5 and Figure S5C ).

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