Significance of initial blood pressure and comorbidity for the efficacy of a fixed combination of an angiotensin receptor blocker and hydrochlorothiazide in clinical practice.

This might be significant especially for older patients with predominantly increased systolic blood pressure. 3) The efficacy is quantitatively not dependent on the presence of a range of concomitant diseases. 4) High compliance of >98% because of a low incidence of adverse events (0.66%) facilitates long-term adequate control of blood pressure.

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