Effect of read-mapping biases on detecting allele-specific expression from RNA-sequencing data.

Bioinformatics · 2009 · PMC2788925 · PMID 19808877

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highly significantno p-value reported

First, averaging across all sites, there was a highly significant bias toward overrepresentation of reference alleles.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.