The NRG1 gene is frequently silenced by methylation in breast cancers and is a strong candidate for the 8p tumour suppressor gene.

Oncogene · 2009 · PMC2789334 · PMID 19802002

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hedged sentence

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The sentences

highly significantno p-value reported

If these cases were set aside, the correlation between lower expression and increasing methylation was clear and highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.