Limited complementarity between U1 snRNA and a retroviral 5' splice site permits its attenuation via RNA secondary structure.

However, in the context of the RNA stem–loop and the extended stem–loop construct, co-transfection of the MS2-SRp55 plasmid led to a highly significant enhancement of splicing ( Figure 5 B and C, compare lanes 3–6; P -value = 0.009 and 0.002).

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