Influence of two vaccination campaigns on genetic diversity of invasive Neisseria meningitidis isolates in northern Spain (1997-2008).

Comparison of the incidence of invasive diseases in children less than 7 years old in the study region between the prevaccination -conjugate vaccine- period (1997–1999) and the postvaccination period (2001–2008), revealed a highly significant reduction, due to a marked decrease in serogroup C cases (incidence rate 11.1 vs. 2.0 cases×100,000 inhabitants, respectively; P<0.001).

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