highly significantp < 0.0029
Kaplan-Meier curves for overall survival showed highly significant differences in patients with remission (R), and no change (NC) or progression (P) at time of staging investigations after the third therapy cycle (p < 0.0029 between R and NC; p < 0.0001 between R and P; Figure 1A ) with median survival times of 528 (R), 328 (NC), and 327 (P) days, respectively.