highly significantP < 0.001
Blood pressure reductions 48 hours postdose were 25.6/16.4 mmHg for candesartan/HCTZ and 9.2/4.2 mmHg for losartan/HCTZ, with differences between treatments being highly significant in favor of candesartan/HCTZ (16.5/12.2 mmHg; P < 0.001).