Endothelin signalling in arterial smooth muscle is tightly regulated by G protein-coupled receptor kinase 2.

Cardiovasc Res · 2010 · PMC2802200 · PMID 19748906

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highly significantno p-value reported

These data indicate that inhibition of endogenous GRK2 activity results in a highly significant attenuation of ET-1-induced ET A R desensitization.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.