Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria.

In Lmna HG/+ mice, the FTI reduced disease phenotypes in a highly significant manner, but the drug had no effect in Lmna nHG/+ mice.

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One could argue that there may have been a slight trend toward improved body weights and lower numbers of rib fractures in FTI-treated Lmna nHG/+ mice, but these differences did not achieve statistical significance.

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