Decreased serotonin level during pregnancy alters morphological and functional characteristics of tonic nociceptive system in juvenile offspring of the rat.

Moreover, pCPA treatment of the pregnant rats compared to saline treatment produced in offspring a highly significant decrease in duration of the second phase of the response to formalin, both in female pups (flexing+shaking, p < 0.006, Fig. 2 Aa; licking p < 0.002, Fig. 2 Ba) and male pups (flexing+shaking, p < 0.02, Fig. 2 , Ab; licking, p < 0.01, Fig. 2 , Bb).

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