The observed differences at a protein level in IL-6 expression of 1.7- to 2-fold associating with LEP genotype may be clinically highly significant, emphasising the potential disease relevance of these data.
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An integrated expression phenotype mapping approach defines common variants in LEP, ALOX15 and CAPNS1 associated with induction of IL-6.
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The sentences
An adaptive algorithm was used which speeds computations by dropping SNPs less likely to be significant in each iteration.