Array-based DNA methylation profiling of primary lymphomas of the central nervous system.

Identification of genes differentially methylated between PCNSL and hematopoietic controls PCA based analysis applying most stringent conditions differentiates normal controls from both PCNSL and systemic DLBCL samples in a highly significant fashion (p = 1.2 × 10 -12 , q = 3.9157 × 10 -11 ; Fig. 1A ). 33 CpG loci (corresponding to 30 genes) differentiating between PCNSL and controls performed in replicates were significantly hypermethylated while three CpG loci showed hypomethylation in PCNSL compared to hematopoietic controls (Fig. 1B ).

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