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The Pfam protein families database.

Nucleic Acids Res · 2010 · PMC2808889 · PMID 19920124

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an overall trendno p-value reported
Proteome coverages While we have focused on the highs and lows in terms of performance, there is an overall trend towards an increase in coverage.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.