Joint effect of MCP-1 genotype GG and MMP-1 genotype 2G/2G increases the likelihood of developing pulmonary tuberculosis in BCG-vaccinated individuals.

The increments in luciferase activity produced by the addition of increasing amounts of human rMCP-1 to antigen stimulated cells were significant for the allele 1G (ANOVA F = 10.23, p = 0.005) and highly significant for the allele 2G (ANOVA F = 172.3, p <0.00001).

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tuberculosis -antigen stimulated cells transfected with vector containing the -1607 MMP-1 allele 1G expressed higher luciferase activity than non-stimulated cells transfected with the same vector, but the difference was marginally significant (t = 2.48, p = 0.048) ( Figure 4 ).

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