Genomic study of replication initiation in human chromosomes reveals the influence of transcription regulation and chromatin structure on origin selection.

Mol Biol Cell · 2010 · PMC2814785 · PMID 19955211

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highly significantp < 0.0001actually significant

Interestingly, these initiation peaks were enriched (68%) in the genomic segments 5 kb upstream or downstream of the TSS, and this correlation was highly significant compared with random (p < 0.0001; Figure 4 , A and B).

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