Drosophila melanogaster p53 has developmental stage-specific and sex-specific effects on adult life span indicative of sexual antagonistic pleiotropy.

Furthermore, while the survival curves of many of the reverse cross pairs differed from one another in both sexes (log-rank test, data not shown), in females there was strong concordance and highly significant results from comparisons of survival curves in both cross directions and relative to both controls, while this was not the case for males (Supplementary Table 8 ).

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