Similarly strong purifying selection acts on human disease genes of all evolutionary ages.

Genome Biol Evol · 2009 · PMC2817408 · PMID 20333184

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highly significantno p-value reported

The difference is less dramatic for the young complex disease genes, but it is still highly significant.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.