Systemic myostatin inhibition via liver-targeted gene transfer in normal and dystrophic mice.

While the mdx 11L and mdx 11H muscle weights were not statistically different, both were greater than control muscle weights and there was a notable trend toward a larger magnitude of muscle growth when myostatin inhibition was initiated at one month of age ( mdx 11H) in comparison to the neonatal period ( mdx 11L) ( Fig. 4D ).

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