Long-term follow-up of the United Kingdom medical research council protocols for childhood acute lymphoblastic leukaemia, 1980-2001.

A major improvement in CNS relapse rate was seen in ALL97/99, where the rate was nearly halved, for both standard and high risk patients, regardless of which steroid – prednisolone or dexamethasone -was given, so that for all groups together there was a highly significant reduction in CNS relapse risk.

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