5 , 6 In rectal cancer, involvement of circumferential resection margins (CRMs) is regarded as a highly significant predictor of local recurrence, prognosis, and survival. 7 – 10 This led to an alteration of practice, with recommendations for preoperative (chemo)radiotherapy with complete resection of the whole mesorectum in order to reduce the rate of CRM involvement. 11 The role of CRMs in predicting local recurrence in esophageal carcinoma was first described by Sagar et al. 12 Subsequently, the role of CRMs in esophageal cancer has been investigated during the past decade.
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A critical appraisal of circumferential resection margins in esophageal carcinoma.
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