E-/P-selectins and colon carcinoma metastasis: first in vivo evidence for their crucial role in a clinically relevant model of spontaneous metastasis formation in the lung.

In contrast to the weight of the primary tumour, the mean value of the number of lung metastases was 481±98 in wild-type scid mice and 75±37 in E- and P-selectin-deficient scid mice, with the differences between the two groups being highly significant ( P <0.0001; see Figure 2) .

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