highly significantp < 0.01
The associations between NYGGF4 levels and disease progression all demonstrated highly significant linear trends (F 1,95 = 17.425, p < 0.01 for CDR score, F 1,85 = 25.053, p < 0.001 for Braak stage, and F 1,96 = 13.102, p < 0.001 for plaque density).