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Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus.

Virol J · 2010 · PMC2825209 · PMID 20122152

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an increasing trendno p-value reported
DENV causes an estimated 100 million infections annually with an increasing trend of many more countries becoming hyper-endemic for all 4 serotypes [ 7 ].

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.