Amiloride inhibits macropinocytosis by lowering submembranous pH and preventing Rac1 and Cdc42 signaling.

J Cell Biol · 2010 · PMC2828922 · PMID 20156964

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highly significantno p-value reported

Even comparatively modest changes in pH produced marked, highly significant decreases in macropinocytic efficiency ( Fig. 4 B ) and virtually complete inhibition was noted at pH 6.8 ( Fig. 4, A and B ).

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