highly significantp = 8.5×10 −8
At an FDR threshold of 0.01, all of the solutions were highly significant ( p = 8.5×10 −8 for NGT-EMRN, 7.4×10 −9 for NGT-CMRN, p = 7.0×10 −15 for IGT-EMRN, p = 0.025 for IGT-CMRN, respectively, Mann-Whitney-Wilcoxon test) indicating that the clustering of metabolite changes in the network is highly non-random.