Global self-regulation of the cellular metabolic structure.

In this case, for several previous transitions, an increment on the phase-shift average value implies an increasing trend in the future.

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Values of H<0.5 are interpreted as characteristic of ‘trend-reversing’ or long-term antipersistence, i.e., the behaviour of the metabolic series tends to reverse itself, an increasing tendency in the past for a sequence of metabolic transitions is followed on average by decreases in the future, and conversely, a decreasing trend in the past is likely to be followed by an increasing tendency.

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