Barely Significant
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Charcot foot reconstruction with combined internal and external fixation: case report.

J Orthop Surg Res · 2010 · PMC2831018 · PMID 20181223

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highly significantno p-value reported
Lower extremity amputation is known to affect a significant increase in cardiovascular output, which is highly significant in the patient population affected by CN.

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Quoted from the open-access full text in Europe PMC under the licence the publisher applied. The sentence is reproduced exactly as published; the emphasis is ours.