(b) Comparing individual miRNAs in the training versus pseudo-training groups, 206 of 257 miRNAs on plate A (100 of 125 miRNAs on plate B) were expressed at higher levels in the training group; this was statistically highly significant ( P = 1.6×10 −17 ).
Several of the miRNAs in the central cluster were significantly up-regulated by training (mir-15a, 19b, 21 and 335-5p), whereas others were up-regulated but did not achieve significance (mir-665), and others (notably the two hubs mir-188-5p and 489) did not show any mean difference in the training versus pseudo-training comparison (see Supplementary material at http://www.asnneuro.org/an/002/an002e028add.htm ).