Activation of PPARbeta/delta causes a psoriasis-like skin disease in vivo.

As shown in figure 1a , both data sets confirm highly significant upregulation of PPARβ/δ in psoriatic skin whereas both PPARα and PPARγ are downregulated, consistent with the notion that PPARβ/δ acts antagonistically to PPARγ in psoriasis, as previously proposed [12] .

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